As per the news in the attached link, malaria parasite have started to adapt to even arthemeter-lumefantrin combo.
So, Will there ever be an end to drug resistance? .... Considering that parasites and pathogens always find a way to adapt..
http://www.npr.org/sections/goatsandsoda/2017/01/31/512716015/drug-resistant-malaria-turns-up-in-the-u-k