Why we should use pocl3/pcl5 mixture in chlorination of pyrimidine and not only pocl3
Dear Ahmed,
Based on my personal experience using pocl3 will lead to the same result.
Yes you can use POCl3 for the chlorination of pyrimidine in the presence of base.
Please see the below link for further information
http://www.mdpi.com/1420-3049/17/4/4533/htm
Both the conditions are permissible but in typical conditions the reaction needs PCl5 to promote the reaction.
Most of the time results will be similar, although in some situations addition of PCl5 could be beneficial. If a particular procedure requires POCl3/PCl5 mixture, I will try to read the paper carefully to understand why it is used instead of just POCl3. Perhaps sometimes POCl3 is of poor quality, then adding PCl5 will certainly help.
http://onlinelibrary.wiley.com/doi/10.1002/jhet.5570210447/pdf
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