07 January 2021 5 1K Report

I am assuming the resulting insertion/agglomeration in the presence of a surfactant or the agglomeration of surfactant may reduce the rate of ionization. The mobility of the ion may also be reduced in the presence of the surface-active agent. Kindly share me the exact/ probable reason / mechanism repression the mass spectra a compound in the presence of surface-active compounds. Interestingly fluorinated surfactants such as perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOSA) could be employed for ESI-MS without a significant decrease in sensitivity!!

Kindly explain/ share your view.


Best Kind Regards

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