It is not a mandatory constraint, but rather a practical issue: in case of leak in your system, you do not want to have air getting inside the ORC. Besides of contaminating your working fluid, the "non-condensable" gas will also rise your condensing pressure and degrade your conversion performance.
In addition to what Remi said: under certain conditions and working fluids, e.g. SES36, sub-atmospheric conditions can occur which require special care in handling and avoiding non-condensables in the ORC system.