Why does somebody ask about the clinical significance of the paper before the study design? We don't know the result but your master needs you to tell him/her the clinical significance of the paper, it is a little bit ridiculous.
I think it may help the reader to know how important your study vs the area of the journal and readership. This is helpful too for the editors to select is the article is pertinent to the journal you have targeted.
Do not confound the clinical significance of the paper vs statistical significance. I interpret the clinical significance as clinical meaning.
I hope this helps, but it is difficult to give a precise answer without knowing some specific context of your problem.
I think the answer is very simple. You first encounter a problem, then you seek solution for that. If a research project would not solve a clinical problem then it is not worth working on from clinical perspective. Of course knowing the answer to every unanswered scientific question may come handy in the clinic at some point in the future, but it's about priorities.
When someone asks about the clinical significance of a paper before discussing the study design, it may be because they are interested in understanding the potential impact and relevance of the research findings in a clinical context. By evaluating the clinical significance upfront, they can determine whether the study design and methodology are worth exploring further.
Here are a few reasons why someone might inquire about the clinical significance before delving into the study design:
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