This my first publication in medical hypothesis journal about
The Possible Immunoregulatory and Anti-Inflammatory Effects of Selective Serotonin Reuptake Inhibitors in Coronavirus Disease Patients
And this link
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7382922/#__ffn_sectitle
In this publication i provides many information about SSRIs medicine should be taken especially sertraline according the following
In general, both stressors and depression are associated with the decreased cytotoxic T-cell and natural-killer-cell activities that affect processes such as immune surveillance of tumours, fighting infection
Also
1. Cytokines storm is main cause of death due to lung fibrosis and already proven in may research before is cause depression due to the fact known about cytokines
Which metabolize tryptophan that lead to depression due to reducing serotonin production and all researchers know the relationship between depression and susceptibility to infection will increase and decrease t cell and immune system
So you can give this medication only for this proven purpose
2.ssri beside it make patients fell well and increased serotonin levels it also work as immune modulator which increases the immune function also adaptive and innate immunity
3. Already proven as antiinflammatory mediator specifically for il_6, 10, TNF and many cytokines types will decrease because Ssri binds to the sigma-1 receptor on immune cells that regulates inflammation by inhibiting the production of cytokines
4. Sertraline (ssri) already have proven clinical trials for increasing the o2 saturation and quality of life for sever and chronic for copd patients
5. Increasing immune system whithout make hyperactivity so can lead to cytokines storm because it regulate cytokines production and suppress its secretion
6. Have also in many research antiviral effect like in ebola virus,
coxsackievirus and influenza viruses
Why not use it without clinical trials based on the inevitability of depression associated with the release of cytokines In late cases of Covid-19 to prevent symptoms of depression associated with cytokines release in late stages Why is it not taken at the beginning of the disease before the onset of complications
One fear is most of the SSRIs when given along with HCQ or Azithromycin increases the risk of QTc prolongation.
Ok this problem is very rere and you can use another antibiotics
There is literature to support repurposing of SSRI's to treat COVID-19 but risks include impaired coagulation and cytochrome mediated drug interactions, particularly for fluvoxamine, for which there are trials in progress.
Yes, fluvoxamine is speculated in some case reports, but there is no quality evidence for SSRI treatment in COVID-19.