Generally, We have been told to make social distancing and all others rules to follow, and we have been following since the pandemic situation started in whole world as our government advised. But, why it is more dangerous for the people who are 60 or more than 60 years, also if they are diabetics or they have high blood pressure. What kind of precaution they can take, if they visit to doctors or emergency work.
COVID-19 is more harmful for older people because of associated co- morbidities such as hypertension, diabetes, chronic obstructive pulmonary disease (COPD) and chronic kidney disease (CKD).
We know that over 95% of the deaths occurred in those older than 60 years. Some of the reasons older people are greatly impacted by COVID-19 include the physiological changes associated with ageing, decreased immune function and multi-morbidity which expose older adults to be more susceptible to the infection itself and make them more likely to suffer severely from COVID-19 disease and more serious complications.
Because of their weak immune system. but there are cases were above 100 years persons also survived from this COVID . It ultimately depends on the immune system one have
Due to non communicable disease of aged person and weaker immune system.
Following articles discuss the reasons why older people are at high risk to die during the COVID-19 pandemic? It boils down to poor immunity and increased comorbidities in the elderly as the cause.
1. Preprint The COVID-19 pandemic in an aging world
2. Article Ageing and COVID-19: What is the role for elderly people?
3. Preprint COVID-19 is an emergent disease of aging
4. Article COVID-19 is a disease of older people
5. Preprint Adverse Outcomes for Elderly in Covid-19: The Loss of the Lo...
Respected Smrity Dwivedy,
The mitochondrial bio-energetics is significantly compromised as we age due to functionally impaired Charnoly body (CB) formation and charnolophagy (CB autophagy) as a basic molecular mechanism of intra-cellular detoxification (ICD) for normal cellular function to remain healthy and fight against microbial (bacteria, virus, fungus, and parasite) infections. (For details you may refer to my books “The Charnoly Body: A Novel Biomarker of Mitochondrial Bio-energetics, and Zika Virus Disease: Prevention and Cure)
Three clinically-significant protective (physiological, biochemical, and immunological) barriers start down-regulating as a function of aging. Moreover, our physical status, genes, and environment play a pivotal role in predisposition (susceptibility and resistance) to COVID-19 infection and its prognosis. That is why all old persons >60 are not equally susceptible to COVID infection. However, with pre-existing conditions (HTN, obesity, CVDs (atherosclerosis), cerebrovascular diseases, smoking and drinking habits are more susceptible to COVID-19 infection and its deleterious consequences.
Particularly, COVID-19 compromises charnolophagy in the macrophages, neutrophils, and lympoctytes of highly vascular, condunctive, and vulnerable organs requiring numerous mitochondria for the generation of energy (ATP) through oxidative phosphorylation in the electron transport chain, including Lungs, GIT, Cardiovascular, Musculo-Skeletal, Renal, and CNS Progenitor (Stem) Cells requiring constant synthesis, repair, and rejuvenation of mitochondria to remains alive.
Due to charnolosome (CS) destabilization, a process known as Charnolosomaging (CB molecular pathogenesis-linked aging) is activated to trigger infalmmaging (inflammasome activation, IL-1β, IL-18, TNFα, NFƙβ, PDGF, TGF-1β, MMPs and TIMPs and caspase-1) involved in fibrosis and tissue remodeling due to induction of charnoptosis (CB-linked apoptosis) followed by pyroptosis (inflammatory cell death) particularly in aging. Three important pore-forming proteins Panx-1, Gasdermin, and Viroporine plays a crucial role in cellular deterioration, early morbidity, and mortality. We need to develop antagonists for them to combat this virus.
The concentration of histamine (H-1) receptors on the mast cells and basophils in the nasopharyngeal and bronchial airways and angiotensin-converting enzyme (ACE) on the pulmonary epithelial cells and alveolus with which COVID-19 binds to invade and trigger acute respiratory distress syndrome (ARDS) and pneumonia involving fever and inflammation are significantly are increased in aging.
However, age is one of the several precipitating factors in the severity of COVID-19 progression and poor prognosis. There are now reports available that women are relatively less susceptible to COVID-19 presumably due to highly intricate and sophisticated hormonal (estrogen, progesterone) system.
Currently, we lack appropriate preventive (vaccine) and/or therapeutic (antiviral) measures to combat this virus. As in the past, we are relying on our own immune system to fight against its deleterious pore-forming (Viroporine) proteins, spike (S) proteins, and RNA.
Definitely we need a vaccine and other therapeutics for its prevention and cure. As a function of time, we will also develop immunity to remain healthy and alive at any stage of our life. Meanwhile, I would suggest to eat healthy diet rich in vitamins, micro-nutrients, and antioxidants and do moderate exercise regularly to remain healthy. However, these are only health-promotive measures. That is why, there is considerable inconsistency in the clinical prognosis of COVID-19 or other existing viruses in the environment. Let us hope that this virus does not mutate frequently which will definitely help to combat its deleterious consequences.
Respectfully submitted,
Sushil Sharma, Ph. D; D.M.R.I.T
Academic Dean
American International School of Medicine
Georgetown, Guyana, South America
Because of having low immunity as people with 60 and above mostly having underlying medical conditions so that was also the cause of it.
Simply weaker the immune system more prone to COVID-19.
I think it is mainly people > 65 years. I also think the management of their health prior to Covid-19 put them at risk for poorer outcomes
Older adults are at a significantly increased risk of severe disease following infection from COVID-19. This is a very important observation for the European Region: of the top 30 countries with the largest percentage of older people, all but one (Japan) are our Member States in Europe. The countries most affected by the pandemic are among them.
We know that over 95% of these deaths occurred in those older than 60 years. More than 50% of all deaths were people aged 80 years or older. We also know from reports that 8 out of 10 deaths are occurring in individuals with at least one underlying co-morbidity, in particular those with cardiovascular diseases/hypertension and diabetes, but also with a range of other chronic underlying conditions.Three important points should be considred;
First, we should emphasize that while older people are at highest risk from Covid-19, all of us, at all ages, need to act in solidarity to prevent the further community spread of the virus.
second point is on the importance of supporting all health and social care workers equally and giving special attention to those who provide nursing and social care services for older people: leaving no one behind.
Third points, supporting and protecting older people living alone in the community is everyone’s business.
Ref.WHO.
regards
Older patients are definately more at risk for Covid 19, especially if they have Diabetes and or Hypertension. Having said that, if they manage to control their Blood sugars and Blood Pressure well, they then have the same risk as a normal individual.
people of more than 65 years of age are more vulnerable and.are more at risk for Covid 19 as such individuals have lower immunity alongwith low antioxidants levels and possibly lower fiber contents in the diet.Possibly these individuals have also lower Vitamin D levels . I think all the abovementioned parameters compromised levels make an individual of more than 60-65 years of age more vulnerable for Covid 19 infection.
Older adults are more likely to have underlying conditions such as cardiovascular disease , diabetes, COPD etc. As we know comorbidities increase the risk of serious COVID-19 and COVID-19-related death. Additionally, a likely weaker immune system will make it more difficult for older adults to fight off infection.
Generally speaking older patients above 60-65 have weaker general immunity as well as weaker local immunity of the lung. Older patient are prone to chronic diseases such as hypertension and diabetes which further aggravates the state of lower immunity. Patients with hypertension and diabetes have an upregulation of ACE2 receptors which are used by COVID 19 coronaviruses for invasion of cells.
Mainly due to immunity power and may have other deceases like BP, sugar or others.
People older than 60 to 65 years usually have more comobidities than younger people, like high blood pressure, diabetes, cardiovascular and pulmonary diseases, cancer, etc. Also older individuals have depressed the immunity system in comparison with younger people. Also it is necessary to have in mind the probable use or prescription of some type of drugs as ACE inibitors and ARBs.
COVID-19 is more harmful for older people because of associated co- morbidities such as hypertension, diabetes, chronic obstructive pulmonary disease (COPD) and chronic kidney disease (CKD).
I feel its because the natural ageing process of the body. The older one becomes, the body weakens physically and/or cannot function as it did whilst in its prime. This can therefore mean that the immune system also gets weaker, and also susceptibility to other conditions such as BP, Diabetes, and other chronic illnesses.
COVID 19 more harmful for the peoples who are 60 or above 60 years due to several factors:
- Comorbid conditions like: Diabetes, Hypertension, Heart diseases, COPD, Bronchial asthma etc
- The age-related decline in physiological functions, attributable to reduced organ reserve and gradual functional decline in various organs in the elderly, is the key factor.
- There are certain socio-economic reasons, as well. The elderly people are prone to experience a drop in the quality of life and neglected healthcare, which compromises their health in general and when exposed to Covid-19. Source: Preprint Adverse Outcomes for Elderly in Covid-19: The Loss of the Lo...
Because of the immunity, as the immunity decreases in the elderly as well as in people with other diseases, especially respiratory diseases.
People over 65 are more vulnerable and more at risk for Covid 19 because they have lower immunity. Concomitant chronic diseases also increase the risk of infection.
Hidden cases are also make everyone more vulnerable due to inadequate testing.
Be of their less immunity as compared to other ages, also they have suger blood and pressure blood
Because the immune system of these elderly people is weak compared to non-elderly people.
I have observed that early diagnosis and initiation of treatment (favipavir, hydrochloroquine) significantly slows the progression of the disease in Turkey.
People older than 65 years usually have less immunity for infectious diseases including of course COVID-19. Also they have more comorbidities that youger people like CV disease, hypertension, diabetes, obesity, cancer, etc.
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