Dear Asif,

you rise a very interesting question opening new frontiers in blood pressure research.

Thousands of women and babies die or get very sick each year from the dangerous condition called preeclampsia, a life-threatening disorder that occurs only during pregnancy and the postpartum period.

Preeclampsia (as well as the related disorders such as HELLP syndrome and eclampsia) is most often characterized by a rapid rise in blood pressure that can lead to seizure, stroke, multiple organ failure and death of the mother and/or baby.

We are unparalleled searching new biomarkers in people that have been or will be affected by the condition – mothers, babies, fathers and their families, but also studying human pathology which presents some overlapping conditions (like chronic venous disease, CVD).

We are steadfast in our resolve to improve diagnosis, management and prevention of CVD and we would like to try some experiments also for preeclampsia through research and improved health care practices.

In the meantime, because all pregnancies are at risk, our best defense against the worst outcomes is to ensure patients understand and appropriately respond to the warning signs of preeclampsia. The problem is, few people are aware and adequately informed.

Then, we urgently need to perform biochemical search of new (panel) of biomarkers, such as MMP circulating in blood, as highlighted in CVD; in this case, we have also found promising therapeutic approach.

We hope to inform you and all people interested to the news from the labs; we are also open to joint collaborative works, especially for proteinase profile in pre-eclampsia.

all the best

Ferdinando

Preeclampsia does not happen where there is adequate micro and macro nutrients.

In addition, eating a bulb (not one piece, but the whole bulb or perhaps 2 bulbs) of fresh garlic daily, will lower blood pressure significantly and prevent eclamptic seizures

Judy,

You would be correct about nutrients issue also applies in the cases of fetal growth restriction. Question we need to ask what is specific about PE cases. It is interesting that eating a bulb of garlic lowers bp. Question is why and how.

Ia,

No. We have spent far too much time trying to find the cause for PE by trying to think it emulate other systemic disorders. Unfortunately, most studies have looked at PE as we sometimes view a car race at the finishing line. Finding a cause may elude us but finding ways to eliminate the signs of PE is now withing our grasp (this may also hold true for some elements of the cause too). At the beginning of this century our laboratory took on a different approach from the norm. We asked not what causes PE but what is it that keeps over 90% of pregnancy safe. We looked for protective factors not just those which induce the harm. We found that PE may stem from partial loss of what I have termed "the endogenous cytoprotective pathway against PE" ((Ahmed et al, 2000). These include Hmox1 and now also Cth. There may be others, which collectively protect the placenta from harm. We need to spend more time looking for novel therapies based on scientific rationale.

Would you please kindly read the following manuscripit. Possibly you might have some idea for your question. New insights into the role of aminopeptidases in the treatment for both preeclampsia and preterm labor.

2013 Nov;22(11):1425-36. doi: 10.1517/13543784.2013.825248. Epub 2013 Aug 10.

The various new discoveries such as prostaglandins and endothelins and so on by basic scientists resulted in the failure of fainding a treatment of preeclampsia .Although these new substances were attractive for making new manuscripts for researchers, however we should reconsider that preeclampsia fade away as soon as possible fetal death or delivery.In other word the existence of live fetus in utero:cross-talk between fetus and moter is essential for this disease .

We shoud be careful for attractive bioactive substances newly founded by basic scientists for finding a treatment for preeclampsia.

We have failed to find a treatment for preeclampsia because we know too little about its' pathophysiiology/aetiology.

Regards.

The cytoprotective pathway of heme oxygenase-1 and cystathionine γ-lyase (CSE), which generate carbon monoxide (CO) and hydrogen sulfide (H2S), respectively, hold promise for preeclampsia therapy because of their unique ability to suppress the antiangiogenic state, systemic inflammation, and oxidative stress. Drugs which activate these pathways will help resolve preeclampsia. Go try. Read - Wang K et al, Circulation. 2014;129:e517-e518, doi:10.1161/CIRCULATIONAHA.114.010273

Here in the review attached is what I propose as an answer to my the question above why we have failed to find a treatment for preeclampsia so far and why we are now closer today then we have ever been before in finding a treatment for preeclampsia.

Article Unraveling the theories of preeclampsia: Are the protective ...