Dear colleagues, it’s a well known fact that estriol is successfully used for the treatment of the genitourinary menopausal syndrome (GUMS) in a lot of countries. But except the US. FDA’s experts say estriol is not safe as well as not effective. I’ve tried to find an explanation to this discordance but failed. At the same time some north-american doctors at their internet forums suggest that it’s only due to pressure of the manufacturers who produce conjugated equine estrogens on FDA.
I appreciate your comments.
Dear Maskin
Greetings.
Good evident exist regarding the use of E2 in urinary and hot flushes in menopausal women from WHI. I do not think that this was endorsed by any agency.
Dear Mohamed,
thanks a lot for your kindly answer. Unfortunately, WHI research was dramatically compromised by a great amount of elderly participants, and i'm sure you know about this fact. Nowadays we have 2016 IMS Recommendations on women’s midlife health and menopause hormone therapy ( http://www.tandfonline.com/doi/abs/10.3109/13697137.2015.1129166?journalCode=icmt20 ), and this is the most up to date guidlines now... You mentioned E2 but my question was about E3 (i suppose it's only occasional misprint). If in fact, a great amount of studies was published concerning the effectiveness of E3 but americans still disclaim... Do you use widely E3 for GUMS treatment in your country?
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