Though pycnogenol contain lesser amount of procyanidines (65-75%) where as grape seed extract can contain up to 95% but still the most prescribed dose of pycnogenol is 150 mg whereas of grape seed extract is 300 mg. Can anybody suggest or share some reference why it is like that?
Look here at the source for the best information.
http://www.pycnogenol.com/partenaires/clinical-dosage-calculator/?L=1,
Dear Michael
I already gone through this site. my question is having a "Relative prospective"
In more elaboration its is as follow:
For example, if we see use of pycnogenol in type 2 diabetes, clinical research says maximum effect one can obtain till 200 mg/day dosage after that effect will have plateau at 300 mg dose. this is one thing. Here i'm considering the following:
OPCs in pycnogenol = 65- 75% (as per USP monograph)
Recommended dose based on clinical studies = 125 -200 mg/day --- (1)
On other hand Clinical trial of grape seed extract recommend usage of 600 mg/ day for same indication and same responses
Now consider the following:
General standardization of grape seed is for OPCs = 80 - 95%
Dose recommended = 600 mg/ day -- (2)
So my question is If grape seed contain same therapeutic moiety as pycnogenol that too in higher amount why its dose is more?
Looking forward to hear from you for a good discussion
Regards
Hitesh
If I remember right, pycnogenol contains procyanidins whereas grape seed extract also contain prodelphinidins. The average molecular weights are also different, but that is VERY dependant on extraction method. You might also look up comparison with cocoa procyanidins, closer in structure to pycnogenol.
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