Hello everyone. I need to have some insights concerning what refers to the use of albumin 5% to manage hypovolemia and the use of albumin 25% to manage hyponatremia.
Why does the albumin concentration differ in these cases?? What are the motives for the different concentration of albumin for each situation pointed??
Thanks!
The use of different albumin concentrations (5% vs. 25%) in managing hypovolemia and hyponatremia is based on their distinct physiological effects and clinical goals:
There is no clear evidence for use of albumin in hyponatremia.
https://eglj.springeropen.com/articles/10.1186/s43066-024-00350-7
But sever hypovolemia after adequate resuscitation with blance crystaloids we can use albumin.
https://trialsjournal.biomedcentral.com/articles/10.1186/s13063-020-04921-y
Hi Eduardo,
Everything is about concentration of the Albumin. (please see the PDF, with very interesting Table: Comparison of Therapy Components)
Albumin 5% for Hypovolemia and rapid volume expansion (direct increase in plasma volume without significantly altering the fluid balance), while Albumin 25% for Hyponatremia. Hyponatremia is a condition characterized by low Na levels in the blood. Albumin 25% is used because it has a higher oncotic pressure (see the table), which can draw more fluid into the bloodstream from the interstitial spaces. Also, Albumin is used because it is iso-oncotic with human plasma.
Hope this helps, Filip
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