What is the reason to publish and mislead the society?
Dear Seyed: Very frequently, well known reactions are used in research work to, for example, test the performance and benefits of a new catalyst development. Thus, the first commercial catalytic cracking process to obtain synthetic gasoline was introduced in 1937, using an acid treated natural clay as a catalyst. Then, in 1940, synthetic amorphous silica-aluminates substituted clays. In 1962, very active and highly stable zeolite-based catalysts were discovered and used in the first fluidized catalytic cracking process (FCC). Since then, more than 1000 different specifications of FCC catalysts have been developed and still research in going on to improve, even more, the yield, octane selectivity, life of catalyst, operations and environmental conditions.
In the specific case of the Biginelli reaction for the synthesis of dihydropyrimidones, compounds for pharmaceutical applications, studies leading to increase selectivity and reaction rate under less severe and environmental impact and also to switch from homogeneous to the less demanding heterogeneous catalytic process are, surely, justified.
Therefore, thanks to the effort of the scientific society old reactions and processes are constantly being reviewed in order to make them more efficient, useful and harmless to the environment, for a better world. Welcome!
For example Biginelli reaction has been discovered more than a cetury ago and has been performed under solvent-free and catalyst free conditions
(Org. Process Res. Dev., 2002, 6 (6), pp 817–818, 10.1021/op0255478)
http://pubs.acs.org/action/doSearch?action=search&searchText=catalyst-free+solvent-free+biginelli&qsSearchArea=searchText
but even after this article new catalysts have been proposed for this reaction!!!!!!!!!!!!!!!!!
While I don't know the context of the proposed new catalysts they probably have a reason - perhaps it is to improve the yield or perhaps speed up the process or even a purer product?
Dear Seyed: Very frequently, well known reactions are used in research work to, for example, test the performance and benefits of a new catalyst development. Thus, the first commercial catalytic cracking process to obtain synthetic gasoline was introduced in 1937, using an acid treated natural clay as a catalyst. Then, in 1940, synthetic amorphous silica-aluminates substituted clays. In 1962, very active and highly stable zeolite-based catalysts were discovered and used in the first fluidized catalytic cracking process (FCC). Since then, more than 1000 different specifications of FCC catalysts have been developed and still research in going on to improve, even more, the yield, octane selectivity, life of catalyst, operations and environmental conditions.
In the specific case of the Biginelli reaction for the synthesis of dihydropyrimidones, compounds for pharmaceutical applications, studies leading to increase selectivity and reaction rate under less severe and environmental impact and also to switch from homogeneous to the less demanding heterogeneous catalytic process are, surely, justified.
Therefore, thanks to the effort of the scientific society old reactions and processes are constantly being reviewed in order to make them more efficient, useful and harmless to the environment, for a better world. Welcome!
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