Hello Jian-young,
Interesting question. May be it is because the delta oscillation reported to have both cortical and thalamic components. Thus, both sources contribute to the frequency content of the EEG.
McCormick DA, Bal T. Sleep and arousal: thalamocortical mechanisms. Annu Rev Neurosci 1997; 20:185-215.
Best regards, T
This is very possible Jun. When we applied EEG source localization eLoreta for the analysis of delta waves in healthy young adult, we observed different localization of the delta wave extracted from different sleep stages. This observation favours different origin of slow oscillation in sleep.
Thanks a lot, Tatyana and Jun. In a review by Astori and Wimmer, SK2 channel has been mentioned, that interplay with the Cav3.3. May be this large K current can speed up the frequency?
Astori S, Wimmer RD, Lüthi A. Manipulating sleep spindles--expanding views on sleep, memory, and disease. Trends Neurosci. 2013, 36(12):738-48.
Frequency of waves appear to be function of the size of neuronal map involved in oscillation. higher number of neurons involved in synchrony/oscillation lower frequency observed.
This seems to be linked to the Hebb Law (second law). Function of slow wave sleep appears to globaly decrease global synaptic weight and restore ability to memorize new patterns.
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