When we implant PLA TiO2 bionanocompoiste combination into a biological system what are the things to be considered? Other than Biocompatibility, Antimicrobial and load-bearing capabilities (mechanical properties)
Dear Dinesh Babu Rathina, inaddition to the aforementioned reasons, it is important to known the circulation stability time, and the product of its degradation. My Regards
You have to understand the field where you would like to apply the composite. If you are planning for an implant or packaging application then the desired properties vary significantly. We are working on packaging, and therefore, our focus on thermal and barrier properties.
For all applications, and especially for those concerning the biomedical field, it is highly desired to have a maximum of information about the behavior of polymer composites under the different conditions of utilization. Furthermore, the control of the rate of degradation can be a key-issue in the case of drug delivery systems and of implants made from biocomposites, such as based on PLA.
Going from my practical experience, I will say that function of the nature of PLA (molecular characteristics, isomer purity, degree of crystallinity,…), method of fabrication of composites, composition, thickness of tested specimens, and so on, your product may have some distinct degradation in a typically testing medium, such as PBS. Thus, it is important to do (NB: using specific methods of analysis) your own investigation regarding the degradation your biomaterial.
To be shorter, I will recommend to take as example the following paper that can give you some supplementary ideas:
Samira Benali, Marius Murariu & Philippe Dubois et al., (2015) Key factors for tuning hydrolytic degradation of polylactide/zinc oxide nanocomposites, Nanocomposites, 1:1, 51-61, DOI: 10.1179/2055033214Y.0000000007
Good luck in your research and best regards,
Marius
PS: For eventual interest:
Wu, S., Weng, Z., Liu, X., Yeung, K.K. and Chu, P.K. (2014), Functionalized TiO2 Based Nanomaterials for Biomedical Applications. Adv. Funct. Mater., 24: 5464-5481. doi:10.1002/adfm.201400706
Hydrolytic degradation of polylactic acid (PLA) and its composites, Renewable and Sustainable Energy Reviews, Volume 79, November 2017, Pages 1346-1352
Luo, Yanbing et al. “Biodegradation Assessment of Poly (Lactic Acid) Filled with Functionalized Titania Nanoparticles (PLA/TiO2) under Compost Conditions.” Nanoscale research letters vol. 14,1 56. 14 Feb. 2019, doi:10.1186/s11671-019-2891-4
When PLA is made into a composite, the biodegradation of PLA starts from massive disintegration, which differs from molecular elution and changes over time. Therefore, it is important to design the molecular weight of PLA and the three-dimensional shape and size of the product. As a precaution, it is necessary to confirm in a production process that assumes a temporal reliability test and a durability test by sterilization. I think that we should consider the data necessary for the commercialization regulation.
You can consider biodegradation study of the biocomposite. PLA produced by polycondensation and or ring-opening polymerization methods may have different molecular weights, so you can study the molecular weight effect on the biodegradation. You can also try to use different various forms of PLA including amorphous e.g. poly (DL-lactide), crystalline and or semi-crystalline PLA. This can help you to investigate the biodegradation in details.