rats were given daily dexamethasone in drinking water corresponding to 0.5 mg/kg or 2 mg/kg. These rats are simultaneously fed 25% fat, 3% salt in diet and 10% fructose in drinking water but mortality started at day 8 of daily and increased dramatically.
rats have sever hypoglycemia, reduced body weight before death.
Control high fat/fructose/salt rats seem healthy without mortality so far.
It was noted also that daily subcutaneous injection of dexa to normal rats gave the same results
What would be explanation for this finding?
My assumption is that the dexamethasone in conjunction with the high fat diet, led to an increase in insulin-resistance. I've seen models of diabetes that combine HPA manipulation with high-fat diet to induce a diabetic state. I've attached an article that should help a bit. I hope this helps!
https://www.biorxiv.org/content/10.1101/184507v3.full.pdf
- Badges
- Science topic
- Similar topics
- Chemistry
- Sulfites
- Inorganic Chemistry
- Inorganic Chemicals
- Salts