In the last 4 centuries researchers have pointed out their attention on neurons, as key factors for understanding and cure pain. Results are clearly poor, at least looking to the data coming from epidemiological studies. In my opinion, more helpful explanation would come out, just looking to other cells than neurons, located in the nervous system
Giustino Varrassi
Some claim that the age-related increase in overall pain prevalence does not continue beyond the seventh decade of life. Hope these paper give you some ideas:
Self-reported chronic pain is associated with physical performance in older people leaving aged care rehabilitation
Leani Souza Máximo Pereira et al. Clin Interv Aging. 2014; 9: 259–265.
The individual and societal burden of chronic pain in Europe: the case for strategic prioritisation and action to improve knowledge and availability of appropriate care. Harald Breivik, Elon Eisenberg, Tony O’Brien
BMC Public Health. 2013; 13: 1229.
Ochsner J. 2010 Fall; 10(3): 179–187. Pain Management in the Elderly Population: A Review. Alan D. Kaye et al.
Prog Neurobiol. 2009 February; 87(2): 81–97.Towards a theory of chronic pain
A. Vania Apkarian et al.
Sengstaken E. A., King S. A. The problems of pain and its detection among geriatric nursing home residents. J Am Geriatr Soc. 1993;41((5)):541–544
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