chalcones are the most versatile natural as well as synthetic molecules. which part of the chalcone is associated with skin irritation.
actually , the source of irritation may refer to the carbonyl group interaction with conjugation py system .
It's lipophilic molecules with small partial polarity can penetrate the skin and cause irritation.
http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.670.4236&rep=rep1&type=pdf
https://www.ncbi.nlm.nih.gov/pubmed/26201061
above links may help you
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