The economic literature shows a growing interest on investigating the regional economic performance as a result of changes in macroeconomic policy i.e. monetary and fiscal. The contributions are grounded primarily on VAR models and hence provide empirical insights. The motivation behind rests in the recognition that a better and deeper knowledge about the regional effects may help design a more accurate macro policy. Initial investigations highlight the heterogeneous responses but more research is needed to put at work not only new empirical methodologies but also theoretical economic models.