For drug delivery intramucosally in buccal mucosa which polymer is suitable for sustained release of drug considering its degradation products and toxicity.
Does poly vinyl alcohol(pva), polyvinyl pyrrolidone (pvp) and poly ethylene oxide(peo) are bio-compatible for local drug delivery in buccal mucosa, if so which among them is more bio-compatible?
PEO and PVA are highly biocompatible materials. Though an FDA approved material, there are reported cases of allergic response to PVP(especially when comes in contact with mucous membranes). These polymers are as such not biodegradable. Special conditions like microorganisms are required for their degradation. You may also consider chitosan which is biocompatible, biodegradable and mucoadhesive.
Im not sure you'll be sucessful with having a patient stay compliant with a plastic device in their mouth. I think i id try to nano-size the particles and deliver them sublingually or do something like a lozenge.
Dear Alex,
The drug delivery is for intra mucosally, not as buccal patch or oral thin films etc. and i need suggestion about which polymer material not which form of delivery.
Thank you
If your goal is to use these polymers, you can add antioxidants (beta carotene and / or tocopherol), making the tissues more protected by the toxic action of the monomer.
You can use them along with disintegrating agents. Now a days the work is going on PGA, PGA-Co caprolacton and PGA Co-pentadecalactones etc, Regards
In my opinion chitosan is much safer compared to other polymers. You can also try alginate.
I would suggest gelatin which is a polymer and slightly same as chitosan. only the source is important. but if you are trying to obtain from plant then would go for alginate.
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