Dear colleagues,

I am planning to use PAPS (3′-Phosphoadenosine-5′-phosphosulfate) as a cofactor for sulfotransferases in S9-mediated biotransformation studies. However, I am not sure which salt to order. Most studies use the lithium salt hydrate or tetralithium salt. On the other hand, the triethylammonium salt is the cheapest and has the highest available purity. I am wondering if the different speciation might impact bioavailability or even interfere with the enzymatic reaction per se.

Any input is very welcomed.

Thanks and best regards.

Sebastian