Which order kinetics is followed by Sustained Release Tablets and Controlled Release Tablets??
One need to calculate the order from dissolution data. However from theory we can say that nature of matrix forming agent can tell u about the order of release. And mostly controlled release formulations should give zero order which is practically difficult to achieve except in few technologies like osmotic systems.
Dear Abhishk!
Please evaluate some manuscripts. All the best.
Vladimir
Sustained release formulation follow matrix type of drug release kinetic order. It is also a controlled release formulation. Controlled release formulations are supposed to have zero order drug release kinetics.
One need to calculate the order from dissolution data. However from theory we can say that nature of matrix forming agent can tell u about the order of release. And mostly controlled release formulations should give zero order which is practically difficult to achieve except in few technologies like osmotic systems.
It depends upon the physical form of the tablet and the designed mechanism of release (osmotic pump, polymer monolith, polymer membrane, degrading, abrading, dissolving). There are a lot of texts on controlled release that will help with the theory but theory doesn't always equal reality so there's nothing like running some dissolution testing and seeing for yourself.
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