Which one is the preferred standard control between active Glibenclamide and Glibenclamide tablet to study antidiabetic activity of a crude extract?

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Kailas K Mali

Active Glibenclamide should be preferred over its tablet. As tablet contains some of the excipients which may interfere with the absorption of drug which affects Cmax and tmax. Pharmacokinetic parameters like elimination half life, volume of distribution, and clearance remains same.

O.V. Tovchiga

I am completely agree with Dr. Kailas K Mali. If you have a possibility to use the active substance - surely choose it

Harekrishna Roy

I also do agree with Dr Kailash for Active Glibenclamide instead of tablet