My ester is in a impeded conjugated system.
I tried a conventional hydrolysis protocol using 1 eq of ester + 2 eq of NaOH in methanol reflux for 2h hours, but nothing happens.
Any other idea?
Thank you!
maybe you can try non-alcohol solvent or an aqueous mixed solvent. Nothing happens maybe due to NaOH poorly souble in alcohol solvent.
Wang Jinrong I'll try, thank you.
I would either try KOH or adding catalytic amounts of DMAP (dimethyl amino pyridine)
Jordi Agramunt Thank you for the idea!
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