As part of my work with antisense oligonucleotides (ASOs), I’m exploring the use of different conjugates for improving both delivery and target specificity. I’m particularly interested in learning from others in the field about:

  • Which ASO conjugates (e.g., GalNAc, peptides, antibodies, polymers, etc.) have shown the highest level of target specificity in current research?
  • Are there any conjugates that are proving to be more versatile and applicable across multiple targets or tissues?
  • What factors are driving the choice of conjugates in your current research (e.g., target accessibility, therapeutic area, delivery challenges)?
  • I’d appreciate any insights or examples from your work or studies you’ve come across, especially those that demonstrate promising results in either highly specific or more universal delivery of ASOs.

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