I want to use some complexes as catalysts in organic conversions, but I am not sure whether my complexes will be stable or not. Can anyone suggest which techniques are used to determine the stability of a complex in a solution?
If you want to see stability in solution; you can use zeta potential.
The stability of the catalysis can be accessed from the nature of the complex which one is using. If you give some detail of the nature of the complex then one can suggest.
if you sake pK of that complex ... spectrophotometric or pH potentiometric titration techniques ... then use some equations to calculate pK as well as thermodynamics ... I prefer potentiometric titration ..if it is available at you ... I can provide all you need of calculations...
Please give some more detail are you interested in new compounds or any compound in solution or some thing else.(like pharmaceutical formulation)
yes, i am interested in this trend ... I have designed a program in MS Excel to calculate pKa and thermodynamic parameters of ligand and its metallic complexes at two or three different temperatures and using potentiometric titration ... what do you think to share together in a combined work?
Dear Toka
You can use NMR teqnique to measure the stability of a complex in a solution.
The best one is potentiometry, your compound and the complexes must be soluble in water. You will need to perform one titration without metal to determine the pKa of your ligand and then another one with the metal.
You can measure in that conditions, but you will need to determinte the pKw for your solvent mixture from the one in 100% water. I recommend the following book for Determination and Use of Stability Constants from Arthur E. Martell as it is explained in detail how to perform potentiometries titrations. http://books.google.co.uk/books/about/Determination_and_Use_of_Stability_Const.html?id=eQLwAAAAMAAJ&redir_esc=y
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