What should be the dose of aspirin in rat to induce thrombocytopenia?

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Matthew Sobo

Aspirin won't lead to thrombocytopenia. It will decrease the ability of the platelets to aggregate by preventing the conversion of arachidonic acid to transaxemic acid by binding to cyclooxygenase.

There are other ways to reducing the aggregation of platelets which I won't get in to.

If you need thrombocytopenai, the most common form the drug-induced thrombocytopenia is by using heparin (can lead to formation of auto-antibodies). Though a lot of drugs will have the side-effect of thrombocytopenia.

Alfonso Enriquez

Matthew Sobo do i inject the heparin or put it along with their water. TIA