I'm planning to test an oncolytic virus to tumor mouse model. Tumor will be induced by transplantation of murine tumor cell subcutaneously. According to the animal ethics, we must administer analgesic to the tumor model because the tumor development and pressure will cause pain to the animal.
Because we want to see the proinflammatory effects, such as interferons and other cytokines, to the tumor growth and lymphocytes profile, we need drugs that don't interfere the immune system. What is the best analgesic for this purpose?
Email this persons. She has studied your problem:
Linda R. Watkins, Department of Psychology, Campus Box 345, University of Colorado at Boulder, Boulder, Colorado, USA 80309-0345,
email: [email protected] ;
Using I.de Dios and acute pancreatitis as key words in Medline, you can find the use of this analgesic in any of the papers published in the last 10 years. The approval by the ethical committe and the acceptance for publication in journals with impact should be a good support.
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