We rarely use ProSA in our institution unless the patient shows a complex pattern of under/overdrainage, Shunt Assistant provided with ProGAV shunt is enough in most cases. I think the optimal aperture only could be assessed by analysing ventricle size, neurological status and CSF debits/height in a patient with an EVD or with overnight intracranial pressure monitoring with clinical records.
The combination of adjustable valve and adjustable antigravity device offers multiple possibilities.
For example: In the case of an adult with chronic hydrocephalus, the opening pressure is guided by the Katzmann infusion test, if it has been done, placing it below the same or the B wave pattern if chronic monitoring has been performed. In these patients I advise that the ProSa fits between +20 / + 40 depending on the height of the patient.
In children, the opening pressure may be higher, except in low pressure states, in the equivalent of 6-8 mmHg and the adjusted ProSa considering the height of the child to partially compensate for the hydrostatic gradient.