Hi all, I'm searching for volumes of synovial fluid in sheep osteoarthritis (or cartilage defect) model? Any estimation through experience, publications would help. If you have references to other large animal model or human patients, that would also be helpful.
Many thanks in advanced!
Effects of intraarticular treatment with stanozolol on synovial membrane and cartilage in an ovine model of osteoarthritis Research in Veterinary Science
Volume 94, Issue 3, June 2013, Pages 379-387 Spadan et al. The
aim of the study was to verify the clinical and morphological effects of intra-articular stanozolol or placebo treatment, lasting 3 and 9 months, in sheep in which a femoro-tibial osteo-arthritis (OA) were surgically induced (medial bilateral meniscectomy). I hope this helps.
- Ratcliffe A, Shurety W, Caterson B. The quantitation of a native chondroitin sulfate epitope in synovial fluid lavages and articular cartilage from canine experimental osteoarthritis and disuse atrophy. Arthritis Rheum. 1993;36:543–551.
- Lindhorst E, Vail TP, Guilak F, Wang H, Setton LA, Vilim V, et al. Longitudinal characterization of synovial fluid biomarkers in the canine meniscectomy model of osteoarthritis. J Orthop Res. 2000;18:269–280
- Ameye LG, Young MF. Animal models of osteoarthritis: lessons learned while seeking the “Holy Grail” Curr Opin Rheumatol. 2006;18:537–547.
We work with synovial fluid from clinical horses with OA. The volume is very variably. Some horses with OA has minimal or is not possible to take the sample and others has a great volumen (20 ml). The average is 5 ml.
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