The solubility of aspirin in water is 3mg/ml, but I wanted to create a saline solution with a 2uM concentration of aspirin to spike blood in vitro for platelet aggregometry.
What is the solubility in saline?
I have read papers that use aspirin disolved in 0.5% DMSO as well, would that be better?
To enhance aspirin solubility in water or in saline, a "gradual" addition of sodium bicarbonate (in minute amounts) is needed - with continuous shaking of the solution being prepared.
I hope that this is helpful?
Best wishes.
Farouk El-Sabban
You can try dissolving it first in Ethanol or DMSO and dilute it in saline afterwards. Works nicely for me. If you sonicate it, it dissolves super fast.
Would use Ethanol to dissolve Aspirin then as Carsten stated proceed to diluting with NS.
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