Does thrombophillia have a significant effect on implantation failure and recurrent IVF failure?
Sounds like it does impact IVF success. Whether it is inherited thrombophilia or otherwise.
Ivanov P et al., 2012. Am J Reprod Immunol. 2012 Sep;68(3):189-98.
I'm pretty sure it does. Brenner and his team at Rambam in Haifa have done a lot of work on thrombophilia and high risk pregnancies.
check out http://www.ncbi.nlm.nih.gov/pubmed/21790336
Clearly thrombophilia brings repeat abortions and constitute a major cause of infertility by promoting hypercoagulability of placental vessels. Whether it is genetic and acquired its preventive treatment consists of administering aspirin or heparin in early pregnancy, maintaining treatment until delivery. Current is forced to study mutations in coagulation factors (at least II, V, XII) and MTHFR. Safdarian et al)(Iran J Reprod Med. 2014 Jul;12(7):467-70) found that mutations for factor V and homozygosity for MTHFR are risk factors for IVF faillure . Detachment of placenta, preeclampsia, hypertension or intrauterine growth retardation are other possible complications of pregnancy induced by thrombophilia.
There is connection according to recent literature. I think that there are different groups of patients: 1) with pregnancy complication (diseases as preeclampsia) and no concieving problems, 2) with adverse outcome of pregnancy (as IUGR or stillbirth) regardles of eventual concieving problems, 3) with reccurent abortion and infertility 4) with implantation failure spontaneus or in assisted reproduction (RIF) with concieving problems - sterility. Also, women with first spontaneus concieved normal pregnancy may be cadidates for infertility or sterility in coming pregnancies if carry thrombophilia genes mutations. Total number of coagulation genes mutations is significantly higher in patient with pregnancy complications or implantation failure.
Throughout an entire normal pregnancy, the mother’s ability to produce blood clots in the uterus and the placenta is suppressed. Non-clotting blood freely flows to and nourishes the baby. Some mothers may have certain conditions, both acquired and inherited, where clotting of the blood nourishing the baby is not suppressed. This increased tendency for the blood to clot is called thrombophilia. The resulting clots may cause the following complications to occur:
1. Implantation failure
2. Miscarriages
3. Pre-eclampsia
4. Intrauterine growth retardation
5. Oligohydramnios (low levels of amniotic fluid) 6. Abruptio placenta
7. Premature labor (often caused incompetent cervix syndrome)
8. Unexplained intrauterine fetal death
9. Thrombophlebitis (blood clots in the veins or the arteries during pregnancy)
Any woman experiencing any of these complications needs to be evaluated for thrombophilia.
At the time of attachment of the embryo with the endometrium, the endometrium has reached a certain thickness of (10-14 mm link uterine biophysical profile) and blood vessels have grown into zone three, the top most layer of the endometrium. The hormones of ovulation have opened these blood vessels wider than others and the blood flow never stops. Within 24 hours of attachment the embryo (placental cells) have found these blood vessels, bored into them, opened them up and the nourishment process for the baby begins. In this document we discuss how inherited or acquired thrombophilia can cause the blood to begin to clot off and starve the embryo. This may occur either early or late in pregnancy. This is why you see the long list above of nine complications that can occur when this happens.
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