Dear all,
We currently have a trouble with hydronephosis in 5-weeks male SD rats which being used for our experiments. The clinical results from pathologist stated that our rats (11 out of 15 rats) are unhealthy with hydronephosis, gastric mineralization and cardiomyopathy. SD rats are male and only 5 week old which is quite young and not expected to see hydronephosis.
Is this common physiologic dysfunction in these SD rats or just genetic disorder happening in our rats in Thailand? Any comments would be appreciated.
Thank you David.
In your opinion, in this case hydronephosis caused by environment not by genetic?
Dear Sittisak,
Can you please mention if
1. hydronephosis is unilateral or bilateral?
2. Investigation of ureters & urinary bladder findings
3. Avg. body weights range of these animals
4. findings are symptomatic/ asymptomatic?
considering age of animal I would suspect congenital change but incidence and findings like gastric mineralization and cardiomyopathy limits.
(do you use this terminology frequently in young ones? non-induced cardiomyopathy is routinely referred as age related change in older rats )
Further, if you trace hydronephosis to be congenital, be informed that it is not un-common in rats of few strain.
We have a congenital unilateral hydronephrotic rat that we have inbred, but the hydronephrosis is the solitary abnormal finding as described in our publications.
Hello Linda,
Can you direct me to the place that I can download your paper?
Fichtner, J., Spielman, D., Herfkens, R., Boineau, F. G., Lewy, J. E., & Shortliffe, L. M. (1994). Ultrafast contrast enhanced magnetic resonance imaging of congenital hydronephrosis in a rat model. The Journal of Urology, 152(2 Pt 2), 682–687.
It is on research gate.
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