Hello! I'm doing a literature review regarding injectable formulations and I noticed a convention of using lactic acid within the formulation. The handbook of pharmaceutical excipients lists the purpose of lactic acid as an acidulant. I couldn't find any reference relating to the purpose/rationale behind using acidulants within an injectable formulation.
Best regards!
Mr. Jehad M. Nasereddin. I think you can get detail answer from the following 2 links
1.http://www.lactic-acid.com/in_the_human_body.html
2.https://www.google.com.bd/url?sa=t&rct=j&q=&esrc=s&source=web&cd=4&cad=rja&uact=8&ved=0ahUKEwjC7_7Wv63PAhXBsI8KHSESDPIQFggoMAM&url=https%3A%2F%2Fwww.catalent.com%2Findex.php%2Fcontent%2Fdownload%2F739%2F10311%2Ffile%2Finjectable_pharma.pdf&usg=AFQjCNGoITJ6vH3d6g94G8s1ZQIKyM5B_w&sig2=m8KmG_cVbKzpwqMNxDlvjw
Dear Jehad,
Lactic acid may be used in injectable formulations for the production of biodegradable polymers and microspheres, such as poly(D-lactic acid), used in drug delivery systems.
for more on this compound, please see page 355 in the attached file.
Hoping this will be helpful,
Rafik
also as the component of citrare buffer at different pH,
at pH above 7.0 as source of bicarbonate ions at concentration of 0,012–1,16%
http://www.pharmencyclopedia.com.ua/article/7010/kislota-molochna
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