What is the most preferred solvent for dissolving a sample prior to injection on GC MS especially for degraded dye analysis?
Many organic solvents can be used as long as the solvent has a low boiling point and can solubilize the analytes of interest. Hexane and dichloromethane are the most popular solvents. Hexane for non-polar compounds and dichloromethane for moderate to polar compounds.
Many organic solvents can be used as long as the solvent has a low boiling point and can solubilize the analytes of interest. Hexane and dichloromethane are the most popular solvents. Hexane for non-polar compounds and dichloromethane for moderate to polar compounds.
Which solvent dissolves your sample? It should not be reactive and have a low boiling point! You could use nearly any solvent of your choice but solvents with heteroatoms are avoided so are the high boiler and too polar ones. The LOD (Limit of detection) for your chemical class of products will be different than others, at least with some of the classes, which you could check online. The machine LOD is another issue. The best bet would be to use sub-microliter sample solution in the solvent of your choice! With more details in question, answers can be specific to help you solve your problem.
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