My suggestion is: trying to solve it in a conceptual reference frame that is not optimal.
Here is my example. Kleiber’s Law is Max Klieber’s empirical inference that metabolism scales by a 3/4 power of mass. Accordingly, much effort has been invested in trying to deduce a 3/4 exponent from a mathematically based reasoning. An example is the geometric, fracctally based reasoning in A General Model for the Origin of Allometric Scaling Laws in Biology , 1997, Science , Vol. 276. The 3/4 power relates to energy use. Energy use is the conceptual reference frame. Instead, it appears that a better conceptual reference frame focuses on how much energy distribution capacity increases with increased animal size. In that case, the 3/4 scaling of the rate of metabolism is how evolution responded to the 4/3 scaling of energy supply, to render energy per cell invariant. This is discussed in:
Preprint Size, scaling, and invariant ratios
Preprint From Galileo’s simple case to universal 4/3 scaling
Other examples:
The laws of motion without the concept of inertia (Galileo’s marbles experiments).
The nature of heat without connecting energy, motion and heat.
Equating redshift and luminosity distances for SN 1A. I suspect this is a conceptual reference frame problem.
Do you have other examples?