The most commonly used regimen is 4 g intra venous bolus dose, followed by a maintenance infusion of 1 to 2 g/h by controlled infusion pump.
An arbitrary rule of thumb is to infuse for 24h postpartum or until the onset of diuresis, whichever is later
4 - 6 grams of MgSO4 solution in 20 minutes loading, then proceed with 1 - 2 gr/ hr. There is no real consensus. İntramuscular MgSO4 can also be used but the injections are quite painful for the patient. 5 gr for each buttock a total of 10 gram is recommended by some authors. This is maintained by 5 grams additionally every 4 - 6 hours depending on the patient response.
Avoid Mg So4 in myasthenia gravis and remember that although the incidence is low MgSo4 can cause hypotension when used with calcium channel blockers simultaneously.
Deep tendon reflexes should be monitored for maintenance dose arrangements.
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