I was reading an article related to quantification of non-covalent interactions. I came across a term called 'enforced proximity' in it. As I am a beginner in the field of computational chemistry, I would like to get the physical meaning of the term and would like to know how it is utilized in understanding the molecular recognition process.
Martin Klvana
"These proteins come under a variety of names, such as scaffold, adaptor, anchor and docking, but invariably function by 'enforced proximity,' i.e. by binding at least two signaling enzymes together and directing, coordinating and regulating their action."
Article Functional classification of scaffold proteins and related molecules
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