hello dear

According to the definitions, I think they are not different.

Thank you. That's what I think too, but I do not understand this need to invent another word! This just adds confusion.

Though both terms sound alike, there are some subtle differences between the two.

Mechanobiology is the study of mechanical aspects of biology, including how mechanical forces activate, regulate, control, and influence biological processes. Mechanobiology processes are fundamental to life, including areas as diverse as embryogenesis, tissue growth and adaptation and stem cell control.

Biomechanics, on the other hand, is the study of how physical forces interact with living systems. Hence biomechanics could be treated as the extension of engineering mechanics principles to biological systems.

I think it is the opposite, ie that mechanobiology is an application of the principles of engineering mechanics (Newtonian) to biology. I think it deserves a wide debate since the living systems does not respond to ONLY mechanical forces but also to electrical, magnetic, chemical, etc. .... And then why not use terms such as biophysics, bioengineering , biothermodynamics ... that cater more to living (or open) systems ?

Let we see in J.-F.STOLTZ et all :

biomechanics is the mechanics applied to the living sciences

concept of mechanobiology is the relation between local mechanical parameters and cellular functions

I have not read any of the content, however, the existence of a journal called "Biomechanics and Modeling in Mechanobiology" suggests that Biomechanics encompasses a broader set of subjects and methods than Mechanobiology. The title suggests that Mechanobiology uses Biomechanical techniques for specific inquiry.

The labels used for the study of biological systems: bioengineering, biophysics, biomedical engineering, neuro-biomechanics etc... can get a bit confusing. In many cases there are no clear differences between them. This might be due to the fact that many approaches are needed to fully understand biological systems, as suggested in an earlier post.

Wikipedia is the best site to define words.

According to the definitions(wikipedia),they have different.

Biomechanics is the study of the structure and function of biological systems such as humans, animals, plants, organs, and cells by means of the methods of mechanics.The word biomechanics developed during the early 1970s, describing the application of engineering mechanics to biological and medical systems.Biomechanics is closely related to engineering, because it often uses traditional engineering sciences to analyse biological systems.

Mechanobiology is an emerging field of science at the interface of biology and engineering. It focuses on the way that physical forces and changes in cell or tissue mechanics contribute to development, physiology, and disease. A major challenge in the field is understanding mechanotransduction—the molecular mechanism by which cells sense and respond to mechanical signals.While medicine has typically looked for the genetic basis of disease, advances in mechanobiology suggest that changes in cell mechanics, extracellular matrix structure, or mechanotransduction may contribute to the development of many diseases, including atherosclerosis, asthma, osteoporosis, heart failure, and cancer. There is also a strong mechanical basis for many generalized medical disabilities, such as lower back pain and irritable bowel syndrome.

Source: www.wikipedia.org

I would not say that Wikipedia gives always the best definitions of specific terms. However, in this case I think Wiki's definitions cited by Mostafa Sepehryan seem to make much sense and I would agree, especially on the statement related to mechanotransduction. I would further emphasize that research on mechanotransduction seeks not only for the mechanically influenced molecular pathways of diseases but in first place to explain physiological mechanisms of load and strain induced homeostasis in normal healthy tissues.

I think the simplest way to differentiate them would be, in Mechanobiology study it has more impact on biological aspects where as in Biomechanics study it has more impact on their mechanisms.

Thanks Parthi

New mechanobiology video:

http://bcove.me/5iceze75

Mechanobiology = subset of biology. Biomechanics = subset of mechanics.

Mostafa Sepehryan is correct.

Here are short versions of the two definitions:

Mechanobiology is the study of the effects of forces and deformations on living systems at any scale.

Biomechanics is the study of the mechanical behavior of biologic structures at any scale.

Here is a humble attempt to recap the above:

How mechanical function emerges from tissue structure is studied in biomechanics. How external loading of, e.g., a femur affects stress/strain of the chondrocytes in it also belongs to the field of biomechanics (indeed as A.U.Daniels mentioned - biomechanics is a study at any scale).

How this mechanical loading is transduced into molecular/chemical (and what not) changes in the tissue, and how this results in a feed back into altered mechanical properties of the tissue, is studied in mechano-biology. As Lutz Durselen mentioned the latter feedback plays an important role in homeostatis.

Personally, I tend to think of mechano-biology as biology where the focus is more on mechanical signals such as stress/strain (e.g., fluid shear stress) rather than on molecular/cellular signals, which are traditionally the focus (indeed as Karen Troy mentioned - mechano-biology a subset of biology).

To follow up on Sean Osis, perhaps the inaugural editorial of "Biomechanics and Modeling in Mechanobiology" is worth reading. (http://link.springer.com/article/10.1007/s10237-002-0006-z). The editorial is open-access.

Biomechanics is study of applications to principles of physics to human body like torque,angle of pulley,levers,pulleys,resolution of forces...etc i.e kinetics and kinematics..Mechanobiology is study of what actually occurs at cell or molecular level like K+ ions ,actin myosin cross linkages etc..there is very thin line of demarcation between them.As both will go hand in hand..Pathology at any stage will indirectly or directly reflect in other..

I think the simplest way to differentiate between the two is to think of the scale in which each one operates.

Biomechanics is more related to the scale of body segments, interaction with the surrounding environment, etc. On the other hand, Mechanobiology is concerned more with the level of cells, etc.

The Wikipedia answer is probably fair but missing a lot.

Biomechanics is the erroneous application of Classical mechanics to understanding biology. Classical mechanics developed out of the work of Galilei, Newton and Hooke, among others, who formulated a system of linear 'laws' based on the behaviour of inanimate objects, but biology is not constrained by the rules of Classical mechanics. Living organisms are not just collections of levers and isolated free-body diagrams that over-simplify everything down to some arbitrary minimum; and cadaver experiments do not produce the same results as their living counterparts. 

The whole idea of Levers etc as an explanation of joint mechanics is a reductionist approach that has been around since Borelli (1685) compared the anatomy of human movement with man-made machines of the day - and this notion has remained essentially unchanged ever since. Levers generate bending moments and potentially damaging stress concentrations and it is most unlikely that developing tissues would be able to withstand the disastrous consequences of these. In addition, the nervous system is incapable of controlling the huge complexity of joint movements on its own. So, what started off as a theory to explain biological mechanics, which has never been proved, has become an established principle simply because there was nothing else to replace it - until now.

Mechano-biology, on the other hand, examines the way that mechanical forces influence the behaviour of living structures at every hierarchical level - from molecules, cells and tissues to the complete organism - where each one has an influence on all the others; and from more of a whole-systems approach.

Levin introduced the term biotensegrity to describe the structural principles that must apply at every size scale within every organism and that provide a more thorough explanation of biological mechanics. It is widely accepted in cell mechanics (Ingber; Stamenovic; Wang etc) and described in the haptic system (Turvey and Fonseca), tissue and joint mechanics (Scarr) etc and represents a paradigm shift in the way that we think about structural anatomy.

I still like the old, brief definitions: 

Biomechanics

is the study of the mechanical behavior and properties of living systems. 

Mechanobiology 

is the study of the effect of the mechanical environment on living systems. 

the Mechanobiology is an emerging field of science at the interface of biology and engineering. It focuses on the way that physical forces and changes in cell or tissue mechanics contribute to development, physiology, and disease. A major challenge in the field is understanding mechanotransduction—the molecular mechanism by which cells sense and respond to mechanical signals.but the biomechaincs The scientific study of the mechanics of motion in humans and other animals. Biomechanics is sometimes used by athletes to help analyze and improve their performance

As far as I know, the difference is clear