With accordance to the systematic review and meta-analysis conducted by Zhenzhen Pan et al., about the Diagnostic Efficacy of Serological Antibody Detection Tests for Hepatitis Delta Virus.
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According to the systematic review and meta-analysis, the diagnostic efficacy of serological antibody detection tests for HDV suggests high performance, particularly in detecting HDV IgM and IgG antibodies. The pooled sensitivity and specificity for HDV serological tests were 0.99 and 0.90, respectively. Though it's important to remember that this conclusion is dependent on only a handful and inadequate quality of studies, and that new diagnostic instruments with greater reliability and precision must be developed.
Reference: Pan, Z., Chen, S., Li, X., Gao, Y., Cao, Y., Fan, Z., Tian, Y., Zhang, X., Duan, Z., & Ren, F. (2023). Diagnostic Efficacy of serological Antibody detection Tests for Hepatitis Delta Virus: A Systematic Review and Meta-Analysis. Viruses, 15(12), 2345. https://doi.org/10.3390/v15122345
Findings demonstrate that serological assays are highly accurate in identifying antibodies against HDV, particularly IgM and IgG. Further evidence is need to demonstrate the specific efficacy of serological diagnosis, though. For HDV screening, serological testing is often a good option. For laboratory diagnosis, treatment efficacy analysis, epidemiology, and disease control, the creation of novel serological diagnostic instruments with increased precision and dependability in HDV diagnosis is crucial.
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