What is the clinical evidence for the safety of arginine and citrulline administered orally for children?

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Mike Watson

Hi Asim

Evidence for L-arginine and its use as a supplement to assist in treatment of Duchenne Muscular Dystrophy is varied, see these papers...

Arginine butyrate: a therapeutic candidate for

Duchenne muscular dystrophy FASEB J. 2013 Jun;27(6):2256-69.

Arginine metabolism by macrophages promotes cardiac and muscle fibrosis in mdx muscular dystrophy. PLoS One. 2010 May 21;5(5)

Sathees Waran Thayapararajah

http://www.ncbi.nlm.nih.gov/pubmed/25445598

Free full article: Not good and need more studies. rapidly increase risk for hypotension.

http://naturaldatabase.therapeuticresearch.com/nd/PrintVersion.aspx?id=1245&AspxAutoDetectCookieSupport=1

http://ac.els-cdn.com/S0006291X14018178/1-s2.0-S0006291X14018178-main.pdf?_tid=810ed750-8c7b-11e4-9e88-00000aab0f6b&acdnat=1419542460_e37346f56357985512328c12e6e208b0