I have few water extract of the plants to be used for LCMS/MS. Before injecting the extract to the LCMS/MS, i removed the water first via lyophilization and then dilute it with methanol. Is it possible to do this step for LCMS/MS?
Immerse in water. First, understand the properties of a particular molecule you are interested in. if they are thermolabile, avoid heating your sample or heat to levels below their degradation temperatures. Sxhlet at 40 deg C does that well. Other wise, cold extraction (immerse in water for some hours (24 hrs or 7 days) can do. Then, lymphorize your samples, proceed with methanol...