Dear Md

Reproduction and quantification of an infectious disease is judged by the titre of infectious microbe. So titre of infectious microbe is calculated easily using blood serum from pathogen according to the instructions of the manufacturer,s instructions for diseases having antisera.Also CRP reaction is easy to be made which can give you an indication wheather the patient become septic or no.Contact Medical Supplies Co such as Hi-Tec ,High Lab or Promega.

Thank you Gamal Enan for your answer. I think that is may be a way to find it experimentally from the blood serum.

In epidemiology, The basic reproduction number R_0 is the number of secondary cases which one case would produce in a completely susceptible population. It depends on the duration of the infectious period, the probability of infecting a susceptible individual during one contact, and the number of new susceptible individuals contacted per unit of time.

( https://en.wikipedia.org/wiki/Basic_reproduction_number )

The next-generation matrix is a method used to derive the basic reproduction number, for a compartmental model of the spread of infectious diseases. ( https://en.wikipedia.org/wiki/Next-generation_matrix ). It is completely a mathematically way. However, your answer gave me food of thought. May be the basic reproductive number found by mathematical method can be verify by experimental results from the blood serum.

Hi Rafiul,

What sort of data do you have available? You can estimate R0 a number of ways, depending on information in your datasets. For example, if you have age distributions, there's one method, if you have records of the max. population size susceptible and those infected, you can have another. If i find a good review, I'll be sure to post it here.

Chandresh

Please see the following references

http://booksc.org/book/8878841/caf2e3

http://booksc.org/book/18339367/5c8d0e

http://booksc.org/book/36357572/26f1e6

http://booksc.org/book/5117085/7cbbcb

hanks

Thank you Chandresh Ladva and Maged Gumaan Bin-Saad for your answer.

Next Generation Matrix (Van den Driessche and Watmough, 2002).

I will add that in seasonal diseases, diseases that I have been confronted with recently, and in many other cases, this method certainly doesn't work, particularly because the times are no longer infinite or the system changes his behavior according to the time slots. In these cases, the computation is made intuitively. For the particular case of seasonal epidemics, you should somehow try to calculate a ratio (degree of infection within season n / degree of infection within season n+1) which gives the basic reproduction number.

I hope I helped.

If you are talking about mathematical methods, chapter 5 of the book "Introduction to Mathematical Epidemiology" by Maia Martcheva may be useful. But you need to have a mathematical model first. I have read papers where the authors constructed R_0 from experimental data.

Thank you Israel Tankam and Roger Lui.

I think next generation operator is another way to find R0

Thank you Nauman Ahmed

Goodluck

sir Md Rafiul Islam md rafiul islam sir plz give me references of ur answer plz Md Rafiul Islam ...