Al-khazraji

Please, provide the equation. I think the product's name is wrong ! or missing something !

Good luck

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Chemical data Collections, Vol 28, 2020, 100431.

You can try with Hydrazide, aromatic acids and in presence of POCl3 with organic solvent to get 1,3,4-oxadiazole.

Dr . adel Amer

the name of the produt is written in the journal of chemical and pharmaceutical research,2017,9(6):202-2014 , review artical

Dear Shaima Ibraheem Chyad Al-khazraji, the following document deals with the chemistry of thé compound in question. Attached is its chemical structure. Caution: becarefull with these compounds, they are intrinsicaly explosives. My Regards

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4131560/

Dear Shaima Ibraheem Chyad Al-khazraji, the paper you mention deals with 1,3,4-thiadiazole which is prepared from 1,3,4-oxadiazole (S instead of O). Another interesting document at RG. My Regards

https://www.researchgate.net/publication/285778303_Various_approaches_for_synthesis_of_oxadiazole_derivatives

Thankyou doctor

Dear Dr. Shaima Ibraheem Chyad Al-khazraji, these are additional documents. Please feel free to ask me for any of these documents if you don't have access to. Good Luck

https://www.researchgate.net/publication/277480232_One-pot_Three-component_Synthesis_of_Fully_Substituted_134-Oxadiazole_Derivatives_from_N-Isocyanoiminotriphenylphosphorane_Aromatic_Carboxylic_acids_and_1R---Campherchinon

https://www.researchgate.net/publication/291417409_One-pot_three-component_reaction_for_the_synthesis_of_novel_series_of_full_substituted_134-oxadiazole_derivatives_bearing_pyridine_moiety

https://doi.org/10.1016/S0065-2725(08)60172-5

https://doi.org/10.1016/B978-008044992-0.00506-X

https://doi.org/10.1016/B978-008096519-2.00091-6

https://doi.org/10.1016/j.arabjc.2014.09.003

https://doi.org/10.1080/00397911.2013.879901

DOI: 10.1055/b-003-121802

Al-khazraji

I see that you have edited your question!

Please, find enclosed part of literature survey on the transformation of aromatic carboxylic acid to 1,3,4-oxadiazole.

Good luck

Thank you doctor

Aromatic carboxylic acid derivatives can be converted into 1,3,4-oxadiazole easily by reacting aryl hydrazide with phenyl isocyanate in benzene to get the corresponding N-Phenyl carbamide i.e Ar-CONHNHCONHPh followed by acid cyclization with H2SO4 by heating to get the desired 1,3,4-Oxadiazole.

The cyclization can be achieved by heating Ar -CONHNHCONHPh in refluxing o-dicholobenzene(ODCB).