I need to prepare calibration curve for OH-PAHs metabolites measurement in the range of ng/l by using GC/MS; what is the best solvent for the preparation of standard solutions? should this solvent be dried? how can i dried the proposed solvent if i had to use dried solvent? and finally what measures do you suggest to minimize extra solvent use?
Analytical methods for determining metabolites of polycyclic aromatic
hydrocarbon (PAH) pollutants in fish bile: A review
Jonny Beyer, Grete Jonsson, Cinta Porte, Margaret M. Krahn, Freek Ariese
Environmental Toxicology and Pharmacology 30 (2010) 224–244
For solvent drying,you should have some informations in ORGANICUM(English translation of the original German edition of ORGANIKUM) by B.J.Hazzard.
I do not know the area you work. But if your area is analytical chemistry as mine, you should use the same solvent you use to inject to validate and inject your samples. Thus, the results will be more reliable.
For GCMS ACN and EtAc work perfectly, in my case, I prefer EtAc, but all depends on your compounds and the matrix you work with.
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