The best solvent to prepare phenol and flavonoid extracts is methanol.

Methanol

Thank you!

It is usually use the five prevalent following solvent for preparing and extracting of the phenol and flavenoids compounds.

Methanol, Ethanol, Acetone, Hexane and Ethyl acetate. According to the type of the experiment circumstance and the type of the target organ could be used the aforementioned solvents. For more information, it is better to study the following papers. Good luck

https://doi.org/10.1016/j.crfs.2021.03.011

https://academicjournals.org/article/article1380532263_Ghasemzadeh%20et%20al.pdf

https://doi.org/10.1002/jssc.200700261

https://doi.org/10.3303/CET1864022

https://doi.org/http://dx.doi.org/10.15446/rev.colomb.biote.v18n1.57724

methanol and ethanol are the best solvents

methanol and ethanol and the most suitable. But if you are interested in flavan-3 ols, use acetone

Hello Dear

According to experiments, the mixture methanol: water (20:80)had the greatest effect on the extraction of phenolic materials.

SELECTION OF SOLVENT DEPENDS ON WHETHER TO BE RE-EXTRACTED FROM GUMMY IN NATURE OR POWDER MATERIAL. USAGE OF ETHANOL IS PREFERRED AS METHANOL LEAVES MORE TOXIC RESIDUES.

Methanol and ethyl acetate are the best solvents to prepare phenol and flavonoid

Methanol and ethanol and acetone

The most commonly used solvents for the extraction of phenols and flavonoids are those of medium polarity, such as methanol, ethanol and ethyl acetate. You must consider that some flavonoids are bound to sugars, the so-called glycoside flavonoids, to separate this type of compounds it is more useful to use more polar solvents, such as a mixture of ethanol and water. It is also necessary to consider the use that you will give to the extracted compounds, since if you use them for purification it does not matter how they were extracted, but for biological evaluations or food products it is sought to use less toxic solvents, such as ethanol or ethanol-water mixtures.