Dear friend Jason Francis

8-hydroxy-2'-deoxyguanosine (8-OHdG) is a commonly used marker to detect oxidative stress in various organisms including humans and animals. It has been reported to be a reliable marker for oxidative DNA damage in Schistosoma haematobium infections (El-Lakkany et al., Antioxidant and hepatoprotective role of Egyptian propolis against Schistosoma.....; Dkhil et al., Antioxidant and Hepatoprotective.........). However, other markers such as malondialdehyde (MDA) and protein carbonyls (PC) have also been used to detect oxidative stress in Schistosoma infections (Abdel Moneim et al., Aqueous Extract of Arbutus..........; Arafa et al., Efficacy of Curcumin in Alleviating............). The choice of the best marker would depend on the research question, experimental design, and the availability of resources.

References:

1. El-Lakkany NM, Seif El-Din SH, Sabra AN, Hammam OA, El-Maadawy WH, Badawy AA. Antioxidant and hepatoprotective role of Egyptian propolis against Schistosoma mansoni-induced damage. Parasitol Res. 2015;114(1):39-49.

2. Dkhil MA, Al-Quraishy S, Wahab R. Antioxidant and Hepatoprotective Efficacy of Selenium against Schistosoma mansoni-Induced Oxidative Stress and Apoptosis. Oxid Med Cell Longev. 2016;2016:7297624.

3. Abdel Moneim AE, El-Toweissy M, Abdel Maksoud HA, Al-Olayan EM, Dkhil MA. Aqueous Extract of Arbutus pavarii Inhibits Schistosoma mansoni-Induced Hepatic Injury via Regulation of Oxidative Stress and Apoptosis. Evid Based Complement Alternat Med. 2019;2019:7425471.

4. Arafa HM, Waly MI, Jardak K, Al-Numair KS, Alsaad AMS. Efficacy of Curcumin in Alleviating Schistosoma mansoni-Induced Liver Injury and Fibrosis: A Comparison with Praziquantel. J Microsc Ultrastruct. 2017;5(2):87-96.

There are several markers that can be used to detect oxidative stress in Schistosoma haematobium infections. One of the most commonly used markers is malondialdehyde (MDA), which is a lipid peroxidation product that accumulates in cells as a result of oxidative stress. Other markers that have been used to detect oxidative stress in S. haematobium infections include superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GR).

However, the choice of the best marker to detect oxidative stress in S. haematobium infections may depend on several factors, such as the availability of resources, the sensitivity and specificity of the marker, and the research question being addressed.