Thank you, I've already edited the question since your answer made me realize I didn't express myself correctly. What I meant was: which imaging technique (e.g. Thermic, Hyperspectral, etc.) would be best to acquire images and extract information to assess ulcer development.
Not sure whether your question relates to a clinical setting or research setting - one clinical option is 3-D photographic imaging e.g. http://www.aranzmedical.com/
I think Jing Li's answer was good. I would lean toward a T2 MRI image looking for increase or decrease in water content of the tissues.
It sounds like MRI may not be available to you. I have also seen Terahertz imaging used for determining the water content of tissues.
I think the systematic way to approach this is to think about what characteristics are different in pre ulcerus and normal tissue (water content? blood flow?) and try to image it using a method that can detect those changes.
Once you determine what changes indicate pre ulceration, you could develop and test a metric based on the volume of tissue affected.