I wish to learn LC-MS for my work, and looking out for courses/videos for the same. I wish to learn method development, data analysis and other tips. Any valuable suggestions will be highly appreciated!!
Online Courses and Webinars
- CHROMacademy**: Offers comprehensive training on LC-MS principles, method development, and troubleshooting.
- SCIEX: Provides an "Advanced LC-MS Method Development Training" course that includes hands-on instruction.
- Waters: Features a course focused on LC-MS/MS method development for clinical applications.
No paid or free classes can teach someone the skills and knowledge needed to operate and develop methods to use an LC-MS system. That is an irrational expectation. To learn LC-MS, you must first learn HPLC. Websites and vendor "intro" classes will NOT provide the many years worth of hands-on training and knowledge needed to actually use a system. Proper operation and use of such complex analytical instruments requires many years of hands-on experience, with a specific instrument, running many samples types over time. Do not be misled by sales people eager to take your money (at least the so called "free" classes will not cost you money,just time, but may also provide misinformation too). If you do not have access to professional training, then time spent learning the basic concepts via books, technical websites etc will allow you to learn some of the terminology and concepts, but w/o hands-on instrument time AND a trained user to guide you, you will be very limited in what you can learn.
A good place to start: The classic text [e.g. "Introduction to Modern Liquid Chromatography"; Author(s):Lloyd R. Snyder, Joseph J. Kirkland, John W. Dolan] which describes and illustrates HPLC concepts (and some LC-MS info too) are of great value to read and do not require formal classes. These texts are well worth studying both before and during training to learn the fundamental concepts (something many users never master leading to many errors). However, without an HPLC system to train on, books alone will not allow practical skills to be acquired. While the basic concepts are always the same, each brand and model of instrument are different, requiring different knowledge and experience to use. Initially, learning just the basics of HPLC (which are the most important areas of study, as "MS" is just one of the detection systems used) takes the average scientist 5-years of full-time training, with mentoring, using an actual complete instrument. Troubleshooting and method development skills take much longer. No short-cut is possible to replace the needed hands-on time and experience required.
If you really want to learn practical HPLC and LC-MS operation, then start by getting a job at an industrial company that utilizes these tools in their projects (i.e. A Specialty Chemical Company. Pharmaceutical, Medical or Clinical Lab). You may find an employer willing to train you.
Stefani N. Thomas, Deborah French, Paul J. Jannetto, Brian A. Rappold & William A. Clarke. Liquid chromatography– tandem mass spectrometry for clinical diagnostics. Article Liquid chromatography–tandem mass spectrometry for clinical ...
Ishaq Lugoloobi: The article you reference is a what is known as a "Review article" only. It includes no training material of any kind and is just a very subjective review article citing other articles.
William Letter True, it's a recent review article containing educative LC/MS pros and cons and citing numerous recent papers with modern training materials.
- Badges
- Science topic
- Similar topics
- Chemistry
- Pharmacology
- Pharmaceuticals
- Drugs