Good Day All,
I have new molecular-based diagnostic test which focuses on detecting SNPs in a 10 different genes. The DNA diagnostic test is actually probe based so it is looking at relatively small sequences (e.g. 16-24 base pairs long).
I would like to assess the test's overall accuracy as well as do an in-depth analysis on a set of well characterized clinical samples (perhaps a n~100-200) and am curious about thoughts on how the appropriate statistical test. The test is not a true sequencing 'platform' but it is rather similar.
In my opinion, there are several layers which I can assessed accuracy
I am sure there are many other permutations so I am curious as to the appropriate statistical techniques to evaluate the accuracy, sensitivity and specificity of this test?
Hi Ajit, yes that is the traditional method for determining a test's sensitivity and/or specificity (also known as true positive rate/recall and true negative rate, depending on the discipline).
I do plan on calculating that and I was looking for a more rigorous statistical test to assess the new test's performance.
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