What is the applicability of Covariate adaptive randomization technique?

19 January 2022 1 8K Report

Whether it is feasible to adopt covariate adaptive randomization technique in small-sample (n=40) clinical studies.

No, it is not feasible to adopt covariate adaptive randomization technique in small-sample (n=40) clinical studies. As it is adopted to balance large no. of covariates between the groups. so the sub groups will be small and lose internal validity.

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